The Development of Medicine in 17th Century Italy

 Deborah Swift

My fourth book in the Giulia Tofana series, The Cameo Keeper, focuses on medicine and healing in the 17th Century, a time of significant transformation in Italian medicine. As Europe shifted from the Renaissance towards the era of scientific exploration, Italy became a key centre for medical thought and innovation, blending ancient traditions of healing and herbalism with new discoveries. The old medicine and the new were less-than-happy bedfellows, and the advent of printing meant that men’s version of remedial medicine was more often promoted in written texts than the women’s traditional remedies. Men’s thought was widely disseminated in printed books, whereas women’s cures were left in the kitchen notebooks.

The Old Tradition

At the dawn of the seventeenth century, Italian medicine was still deeply rooted in the classical theories inherited from Greek and Roman scholars such as Galen and Hippocrates. Universities such as Padua, Bologna, and Pisa were renowned for their medical faculties, teaching aspiring physicians from these ancient texts. In my novel, Jacopo has studied at Padua University, but he is now intent on a career in the Santo Spirito Hospital in Rome. Medical education was still emphasising the balance of the four humours—blood, phlegm, black bile, and yellow bile—as the foundation of health and disease.

Above: Early Italian Pharmacy

Below: Anatomy Theatre

But in the new age of medicine anatomical dissection became increasingly important, with doctors such as Giovanni Alfonso Borelli and Marcello Malpighi leading the field. Malpighi, celebrated as the "father of microscopical anatomy" for his pioneering use of the microscope, was able to observe capillaries, organs, and tissues, thus advancing the study of physiology.

Surgeons were often required to show off their skills in public demonstrations, and anatomy theatres were popular entertainment for the rich. Some of these were experiments on the dead, but there were also ‘trials’ on the living. These took the form of ‘competitions’ or ‘trials’ where those competing for a surgeon’s position would have to demonstrate their abilities before a hospital board.


The 17th century was also marked by recurrent outbreaks of plague. The outbreak in Rome in 1656 led to stringent quarantine measures – isolating affected neighbourhoods and the fumigation or burning of infected items. City states established boards of health, enhancing the management of infectious diseases. Quarantine hospitals on city outskirts became a hallmark of the new Italian public health strategy, and in Rome one of the quarantine hospitals that features in The Cameo Keeper is one run by monks, and isolated on an island in the middle of the Tiber.

Herbalism and Pharmacy

During this period, women’s role in healing changed. The old tradition of herbal remedies persisted, but influenced by the new science of chemistry, apothecaries began incorporating chemicals and metals into their preparations. Paracelsian ideas, which promoted chemical remedies over traditional humours-based treatments, began to gain ground. Italian pharmacists and physicians experimented with compounds such as antimony and mercury. (see picture below)

Although women were largely excluded from formal medical education, they played crucial roles as midwives, herbalists, and caregivers. Some women, especially in religious orders, managed hospital wards and contributed to nursing and patient care.

The common people still relied on the cheaper, more available care from the women in their households, and care in hospital depended on how much you could afford to pay.

The seventeenth century in Italy was a time of great experimentation, with the three kinds of treatment offered intersecting - herbalism, pharmaceuticals and surgery. For the first time, documentation existed because of the invention of printing and the ability to disseminate the results of experiments more widely.

The Cameo Keeper takes this experimentation as one of its themes and I thoroughly enjoyed researching the 'new' medicine of the era.